解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR‑382 has been observed in various types of cancers. However, the biological function of miRNA-382 in ovarian cancer is still largely unknown. Here, we found miR‑382 was downregulated in human ovarian ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3241
更新日期:2016-01-01 00:00:00
abstract::Cognate interactions between naïve tumor antigen (TA)-specific T cells and TA-presenting dendritic cells (DCs) are facilitated by secondary lymphoid organs such as lymph nodes or the spleen. These can result either in TA-specific tolerance or, depending on environmental costimulatory signals, in TA-specific immune res...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2015.3197
更新日期:2015-12-01 00:00:00
abstract::We have previously shown that growth of the oral squamous cell carcinoma cell line SAS, is resistant to cetuximab in monolayer culture conditions, even though epidermal growth factor receptor (EGFR) was phosphorylated, but the growth of SAS aggregates was sensitive to cetuximab. In the present study, we demonstrate di...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3215
更新日期:2015-12-01 00:00:00
abstract::Cancer-associated fibroblasts (CAFs) are key determinants in the malignant progression of cancer, supporting tumorigenesis and metastasis. CAFs also mediate epithelial to mesenchymal transition (EMT) in tumor cells and their achievement of stem cell traits. Curcumin has recently been found to possess anticancer activi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3202
更新日期:2015-12-01 00:00:00
abstract::Secretin receptor (SCTR), the G-protein coupled receptor (GPCR) for secretin, has been observed to be upregulated in a few tumor types while downregulated in others, promoting or suppressing the proliferation of tumor cells, respectively. However, little is known about the molecular regulatory mechanism of dysregulati...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3164
更新日期:2015-11-01 00:00:00
abstract::The homeobox transcription factor orthodenticle homeobox 2 (OTX2) plays a critical role in very early neurogenesis, but can become oncogenic when aberrantly expressed later in life. We previously discovered its novel oncogenic role in the malignant childhood brain tumor medulloblastoma and hypothesize an oncogenic rol...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3179
更新日期:2015-11-01 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC), the most common esophageal cancer in East Asia, is among the six cancers with the highest fatality rates worldwide. Unfortunately, multidisciplinary treatment strategies have not achieved satisfactory outcomes. Therefore, novel insights into the molecular biology of ESCC are ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3167
更新日期:2015-11-01 00:00:00
abstract::MicroRNA (miRNA or miR)-506 is a novel miRNA related to the survival of breast cancer patients. However, the mechanism underlying miRNA-506 involvement in breast carcinogenesis remains unclear. In the present study, we found that miR-506 was downregulated in human breast malignant tissues and breast cancer cell lines ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3161
更新日期:2015-11-01 00:00:00
abstract::The cytosine analogue 5'-azacytidine (5'-aza) induces DNA hypomethylation by inhibiting DNA methyltransferase. In clinical trials, 5'-aza is widely used in epigenetic anticancer treatments. Accumulated evidence shows that cyclooxygenase-2 (COX-2) is overexpressed in various cancers, indicating that it may play a criti...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3110
更新日期:2015-10-01 00:00:00
abstract::MicroRNAs (miRs) are short non-coding single stranded RNAs regulating the translation of target mRNAs in normal and cancer cells in which they are frequently dysregulated promoting tumor progression. Cancer stem cells (CSCs) of head and neck squamous cell carcinoma (HNSCC), identified by aldehyde-dehydrogenase express...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3142
更新日期:2015-10-01 00:00:00
abstract::We previously reported that podophyllotoxin acetate (PA) radiosensitizes NCI-H460 cells. Here, we confirmed that PA treatment also induces cell death among two other non-small cell lung cancer (NSCLC) cell lines: NCI-H1299 and A549 cells (IC50 values = 7.6 and 16.1 nM, respectively). Our experiments further showed tha...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3123
更新日期:2015-10-01 00:00:00
abstract::Endothelial cells (ECs), that comprise the tumor vasculature, are critical targets for anticancer radiotherapy. The aim of this work was to study the mechanism by which SU5416, a known anti-angiogenesis inhibitor, modifies the radiation responses of human vascular ECs. Two human endothelial cell lines (HUVEC and 2H11)...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3127
更新日期:2015-10-01 00:00:00
abstract::The human immunodeficiency virus (HIV) protein negative factor (Nef) is important for AIDS pathogenesis. An anti-Nef single-domain antibody (sdAb19) derived from camelids has been previously generated and shown to effectively block the physiological functions of Nef in vitro and in vivo in nef-transgenic mice. However...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3132
更新日期:2015-10-01 00:00:00
abstract::Increasing evidence has confirmed that dysregulation of microRNAs (miRNAs) can contribute to the progression and metastasis of human tumors. Previous studied have shown dysregulation of miR-24 in a variety of tumors. However, the roles of miR-24 in human bladder cancer have not been well clarified. Therefore, we inves...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3117
更新日期:2015-10-01 00:00:00
abstract::Women from ethnic minority groups, including immigrants and refugees are reported to have low breast cancer (BC) screening rates. Active, culturally-sensitive outreach is vital for increasing participation of these women in BC screening programs. Women at high BC risk and who belong to an ethnic minority group are of ...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2015.3063
更新日期:2015-09-01 00:00:00
abstract::Nanoparticles are promising novel drug delivery carriers that allow tumor targeting and controlled drug release. In the present study, we prepared poly butyl-cyanoacrylate nanoparticles (PBCA-NP) entrapped with hypocrellin B (HB) to improve the effect of photodynamic therapy (PDT) in ovarian cancer. An ovarian cancer ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3079
更新日期:2015-09-01 00:00:00
abstract::Bcl-xL is an apoptosis inhibitor that is upregulated in bladder cancer (BCa) and provides an attractive target for molecular therapies. Treatment with specific antisense oligodeoxynucleotides (AS‑ODNs) or small interfering RNAs (siRNAs) were able to sensitize BCa cells to conventional chemotherapeutics. Ten new Bcl‑xL...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3096
更新日期:2015-09-01 00:00:00
abstract::Despite recent advances in targeted therapies and immunotherapies metastatic melanoma remains only rarely curable. The objective of the present study was to identify novel therapeutic targets for metastatic melanoma. A library of 160 well-characterised and potent protein kinase inhibitors was screened in the BRAF muta...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3097
更新日期:2015-09-01 00:00:00
abstract::Mechanisms leading to inhibitory effects of an anti-GD2 ganglioside (GD2) 14G2a mouse monoclonal antibody (mAb) and PI3K/Akt/mTOR pathway inhibitors on human neuroblastoma cell survival were studied in vitro. We have recently shown on IMR-32, CHP‑134, and LA-N-1 neuroblastoma cells that targeting GD2 with the mAb decr...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3070
更新日期:2015-09-01 00:00:00
abstract::Lipomas are the most common soft tissue tumors in adults. They often carry chromosome aberrations involving 12q13~15 leading to rearrangements of the HMGA2 gene in 12q14.3, with breakpoints occurring within or outside of the gene. Here, we present eleven lipomas and one osteochondrolipoma with a novel recurrent chromo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3099
更新日期:2015-09-01 00:00:00
abstract::Survivin is a member of the inhibitor of apoptosis family, which is known to inhibit mitochondrial apoptosis. Survivin is highly expressed in cancers and plays an important role in cancer cell survival, and increased survivin expression is an unfavorable prognostic marker in cancer patients. YM155, a novel small-molec...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3077
更新日期:2015-09-01 00:00:00
abstract::Recent studies show an increased incidence of head and neck cancers worldwide. The present study evaluated the trend in the incidence of head and neck cancers in England during 2002-2011. Data were extracted from the database of Office for National Statistics. The study population was categorised according to age, res...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2990
更新日期:2015-07-01 00:00:00
abstract::Previously, we found that the injection of zoledronic acid (ZOL) into mice bearing tumor induced changes of the vascular structure in the tumor. In this study, we examined whether ZOL treatment could decrease interstitial fluid pressure (IFP) via change of tumor vasculature, and enhance the antitumor efficacy of lipos...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2991
更新日期:2015-07-01 00:00:00
abstract::Primary cilia are microtubule-based organelles that regulate smoothened-dependent activation of the GLI transcription factors in canonical hedgehog signaling. In many cancers, primary cilia are markedly decreased or absent. The lack of primary cilia may inhibit or alter canonical hedgehog signaling and, thereby, inter...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3006
更新日期:2015-07-01 00:00:00
abstract::Metastasis is an important prognosis factor in lung cancer, therefore, it is imperative to identify target molecules and elucidate molecular mechanism of metastasis for developing new therapeutics and diagnosis methods. We searched for metastasis-related proteins by utilizing a novel antibody proteome technology devel...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3000
更新日期:2015-07-01 00:00:00
abstract::Estrogens act through interactions with estrogen receptors (ERs) to play diverse roles in various pathophysiological conditions. A number of synthetic selective estrogen receptor modulators (SERMs), such as tamoxifen and raloxifene, have been developed and used to treat ER-related diseases, including breast cancer and...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3002
更新日期:2015-07-01 00:00:00
abstract::Proteasome activator 28γ (PA28γ) binds to and activates the proteasome in an ATP-independent manner to promote mainly ubiquitin-independent protein degradation in cells. Previously, four transcript variants of PA28γ have been identified, which have been closely correlated with the progression of cancers. In the presen...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2980
更新日期:2015-07-01 00:00:00
abstract::Inflammatory abnormalities have been implicated in the pathogenesis of various human diseases, including cancer. Interleukin-1 receptor antagonist (IL1RN) is a potent anti-inflammatory molecule that modulates the biological activity of the proinflammatory cytokine, interleukin-1. The aim of this study was to examine t...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2917
更新日期:2015-05-01 00:00:00
abstract::5-Fluorouracil (5-FU), often used in combination with levofolene (LF), can induce, as an important side effect, the hand-foot syndrome (HFS) due to toxicity on keratinocytes. This can also damage workers involved in its handling. In the present study, we investigated the mechanisms of the toxicity induced by 5-FU alon...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2904
更新日期:2015-05-01 00:00:00
abstract::Sodium metaarsenite (NaAs2O3: code name KML001) is an orally bioavailable arsenic compound with potential anti-cancer activity. However, the effect of KML001 has not been studied in acute myeloid leukemia (AML). We investigated the anti-leukemic effect of KML001 in AML, and determined the mode of action of KML001. KML...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2899
更新日期:2015-05-01 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC) and acute myeloid leukemia are the major causes of mortality and morbidity in Fanconi anemia (FA) patients. The objective of this study was to investigate the antineoplastic activity of PB, an antineoplastic nutrient mixture (containing quercetin, curcumin, green tea, cruc...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2895
更新日期:2015-05-01 00:00:00
abstract::Overexpression of HIF-1α, a transcription factor responsive to hypoxia, is frequently observed in malignant tumors, which sometimes show resistance to chemotherapy and radiation therapy. Consequently, decrease of HIF-1α through virotherapy offers a logical strategy for the treatment of aggressive tumors. In this study...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2922
更新日期:2015-05-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality worldwide. We have previously reported that LASP-1 is a downstream protein of the urokinase type plasminogen activator (uPA). Here we investigated the role of LASP-1 in HCC by a molecular and biological characterization of LASP-1...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2923
更新日期:2015-05-01 00:00:00
abstract::The expression of myeloid cell leukemia-1 (Mcl‑1), a member of the anti-apoptotic Bcl-2 protein family, has been associated with tumor progression and adverse patient outcome. The aims of current study were to evaluate whether Mcl-1 affects the survival or death of gastric cancer cells, and to investigate the prognost...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2890
更新日期:2015-05-01 00:00:00
abstract::Cervical cancer is a potentially preventable disease; however, it is the third most commonly diagnosed cancer and the fourth leading cause of cancer deaths in women worldwide. Cervical cancer is thought to develop through a multistep process involving virus, tumor suppressor genes, proto-oncogenes and immunological fa...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2873
更新日期:2015-04-01 00:00:00
abstract::The objective of the present study was to establish the individual and combined chemopreventive potential of a widely used non-steroidal anti-inflammatory drug, ibuprofen (IBU), encapsulated in solid lipid nanoparticles (SLNs) for the chemoprevention of pancreatic cancer. The IBU SLNs were optimized using various lipi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2879
更新日期:2015-04-01 00:00:00
abstract::Multiple myeloma is a malignant proliferative disease of plasma cells in the bone marrow and remains largely incurable. Cotylenin A, a fusicoccane diterpene glycoside with a complex sugar moiety, was isolated as a plant-growth regulator. Cotylenin A has been shown to inhibit the growth of various cancer cells. Herein,...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2882
更新日期:2015-04-01 00:00:00
abstract::Pancreatic cancer (PanC) is one of the most lethal malignancies, and resistance towards gemcitabine, the front-line chemotherapy, is the main cause for dismal rate of survival in PanC patients; overcoming this resistance remains a major challenge to treat this deadly malignancy. Whereas several molecular mechanisms ar...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2885
更新日期:2015-04-01 00:00:00
abstract::CD44 and CD133 mRNA expression as cancer stem cell markers in colorectal cancer were correlated with synchronous hepatic metastases and the clinicopathological factors, including patient survival. The CD44 and CD133 mRNA levels in 36 primary colorectal adenocarcinomas with synchronous hepatic metastasis were analyzed ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2844
更新日期:2015-04-01 00:00:00
abstract::Prostate cancer is characterized by structural rearrangements, most frequently including translocations between androgen-dependent genes and members of the ETS family of transcription factor like TMPRSS2:ERG. In a recent whole genome sequencing study we identified 140 gene fusions that were unrelated to ETS genes in 1...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2855
更新日期:2015-04-01 00:00:00